Development of a Scalable, Stereoselective Second-Generation Route for CXCR7 Antagonist ACT-1004-1239 via Chiral Enamine Reduction and a Novel Telescoped Sequence of Transesterification, cis-to-trans Epimerization, and Saponification

已完结 10 由 MR.Wang 发布于 2026/9/17 10:08:40

DOI:10.1021/acs.oprd.3c00446
作者：Gabriel Sch?fer*,?Tony Fleischer,?Aurélien Merot,?Michael Erhardt and Boris Mathys,?
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：The rapid development of a stereoselective route for CXCR7 antagonist ACT-1004-1239 was needed, as the large-scale chromatographic separation of enantiomers was not a viable option for a res

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