Design, Synthesis, and Structure–Activity Relationship of Novel Human TLR1/2 Agonists for Potential Immunotherapy

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DOI:10.1021/acs.jmedchem.5c02011
作者：Qiuyue Fu,?, ,?Yue Pan,?, ,?Peixi Wu,?, ,?Zhuoxian Cao,?, ,?Liu Shi,?, ,?Lan Huang,?, ,?Kui Cheng*,?, and ,?Zhipeng Chen*,?
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：Capitalizing on the advantages of Toll-like receptor 2 (TLR2) small-molecule agonists combining high potency and low toxicity in cancer therapy, we designed and synthesized a novel series of

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