Discovery of a Covalent NLRP3 LRR-Domain Probe: Reversing Renal Fibrosis via Immunometabolic Reprogramming in Organoid and Murine Models

已完结 10 由 susu 发布于 2026/9/20 17:08:04

DOI:10.1021/acs.jmedchem.6c01482
作者：Wen-Hui Wu,&nbsp;Yao Yao,&nbsp;Kang Liu,&nbsp;Zhen-Yu Ma,&nbsp;Lin-Yin Wei,&nbsp;Ya-Xuan Li,&nbsp;Kai-Ming Niu,&nbsp;Jing Cai,&nbsp;Xin-Yue Qi,&nbsp;Hao-Kun Chen,&a
文献类型：期刊论文
补充材料：只需要正文

American Chemical Society (ACS)

Abstract：Targeting the NLRP3 inflammasome is critical for treating fibrotic diseases; however, current NACHT domain inhibitors face mutational escape and limited isoform specificity. The autoinhi

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