Brain Penetration Optimization and Anti-neuroinflammation Evaluation of Potent 6-Methyl-7-azaindol-3-yl-quinazoline DYRK1A Inhibitors for Alzheimer’s Disease

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DOI:10.1021/acs.jmedchem.6c01681
作者：Huanhua Chen,Xinzhu Li,Siyuan Liu,Zhenshu Li,Wenjie Liu,Xinhui Ye,Fangyuan Zheng,Xi Zeng,Junjie Lin,Aizhu Yang,Xinpeng Wang,Mengyu Ren,Xudong Gao,Zihua Xu,Jingming Jia,Qingchun Zhao
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Abstract：Targeting dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) to regulate microglia-mediated neuroinflammation represents a promising therapeutic strategy for Alzheimer’s

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