Discovery of Clinical Candidate IAG933, a Potent YAP-TEAD PPI Disrupter

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DOI:10.1021/acs.jmedchem.5c03009
作者：Markus V?gtle*, , , Holger Sellner, , , Emilie Chapeau, , , Pascal Furet, , , Bahaa Salem, , , Micka?l Le Douget, , , Vincent Bordas, ,
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：The interaction of transcriptional enhanced associate domain (TEAD) and transcriptional coactivator yes-associated protein (YAP) mediates oncogenic functions downstream of the Hippo pathway.

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