Synthesis of Danuglipron: Design and Development of a Robust Telescoped C–O Coupling─Deprotection Sequence

已完结 10 由 wzy2xyj 发布于 2026/8/31 21:57:12

DOI:10.1021/acs.oprd.6c00006
作者：Unjila Afrin,?, ,?Aaron Baldwin,?, ,?Arlene P. Bartolome,?, ,?Nga M. Do,?, ,?Andres R. Faria Quintero,?, ,?David F. Fernández,?, ,?Jonathan Fifer,?, ,?Steven J. Fussell,?, ,?Shanjun Huang,?, ,?Gary R
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：Danuglipron tromethamine (1), a glucagon-like peptide-1 receptor (GLP-1R) agonist candidate, was investigated by Pfizer for the treatment of type 2 diabetes mellitus (T2DM) and obesity. Give

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