Mining the CRBN target space redefines rules for molecular glue–induced neosubstrate recognition

已完结 10 由 YAJ 发布于 2026/8/31 17:38:26

DOI:10.1126/science.adt6736
作者：Georg Petzold,?Pablo Gainza,?Stefano Annunziato,?Ilaria Lamberto,?Peter Trenh,?Laura A. McAllister,?Bradley DeMarco,?Laura Schwander,?Richard D. Bunker,?Mary Zlotosch,?Rohitha SriRamaratnam,?Samuel Gi
文献类型：期刊论文
补充材料：只需要正文

American Association for the Advancement of Science (AAAS)

Abstract：The CRL4CRBN E3 ubiquitin ligase is the target of molecular glue degrader compounds that reprogram ligase specificity to induce the degradation of clinically relevant neosubstrate proteins.

应助信息

求助已完结，文件已删除 如有需求请重新发布求助一键发布

感谢使用Book学术
本站所有文献仅供个人学习和参考，请勿将文件进行传播。共同遵守网站规定和相关知识产权规定。

上一个求助:其它数据库Naturally Fractured Carbonate Reservoir Characterization: A Case Study of a Mature High-Pour Point Oil Field in Hungary 下一个求助:WileyHost cell manipulation by microsporidia secreted effectors: Insights into intracellular pathogenesis