Discovery, Optimization, and Evaluation of Non-Nucleoside SARS-CoV-2 NSP14 Inhibitors

已完结 10 由小小发布于 2026/8/31 16:36:26

DOI:10.1021/acs.jmedchem.5c01155
作者：Michael W. Miller*,?, ,?Cindy Meyer,?, ,?Aitor Garzia,?, ,?Hans-Heinrich Hoffmann,?, ,?Tanweer A. Khan,?, ,?Melissa Egbertson,?, ,?Robert W. Myers,?, ,?Nigel Liverton,?, ,?Stacia Kargman,?, ,?Jada A.
文献类型：期刊论文
补充材料：只需要正文

American Chemical Society (ACS)

Abstract：We recently reported the discovery of TDI-015051, a first-in-class small-molecule inhibitor of the SARS-CoV-2 guanine-N7 methyltransferase nonstructural protein 14 (NSP14). NSP14 plays a cri

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