Impact of Heavy Chain C-Terminal Codons on Recombinant Monoclonal Antibody Expression Levels.

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DOI:10.1002/bit.70223
作者：Kenneth R Carlson,?Sowmya Balasubramanian,?John Herrington,?Chris C Frye,?Ronan M Kelly
文献类型：期刊论文
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Abstract：Advances in process optimization and stable CHO cell line engineering have enabled recombinant monoclonal antibody (mAb) titers above 10 g/L in fed-batch cultures. Despite these advances, th

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