Dual-adjuvanted GPC3 mRNA vaccine delivered by lipid nanoparticles for hepatocellular carcinoma immunotherapy

待确认 20 由 lll 发布于 2026/9/4 9:57:35

DOI:10.1016/j.jconrel.2026.114992
作者：Yuhao Jiang, Jianhong Luo, Chao Liu, Wenliang Xue, Jinyu Liu, Muyaxin Wang, Shasha Shi, Xudong Yin, Xinsong Li
文献类型：期刊论文
补充材料：仅需补充材料
文献链接：https://doi.org/10.1016/j.jconrel.2026.114992

Elsevier

Abstract：Glypican-3 (GPC3) is a sought-after immunotherapeutic target for hepatocellular carcinoma (HCC) due to its tumor-specific expression. However, GPC3-derived peptide vaccines suffer from limit

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