SGLT2 inhibitors activate pantothenate kinase in the human heart

已完结 10 由 terence 发布于 2026/9/7 21:41:31

DOI:10.1126/science.aeh4856
作者：Nicholas Forelli,?Trace Thome,?Deborah M. Eaton,?Kollin Schultz,?Jiten Patel,?Caitlyn E. Bowman,?Ryo Kawakami,?Jae Woo Jung,?Ivan A. Kuznetsov,?Kristina Li,?Jialiu A. Liang,?Kirsten Branch,?Claire Bra
文献类型：期刊论文
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American Association for the Advancement of Science (AAAS)

Abstract：Sodium-glucose cotransporter 2 inhibitors (SGLT2i) reduce mortality in heart failure, but their pharmacological target remains unclear. In this study, we showed that SGLT2i directly activate

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