Precision-engineered STING agonist nanoparticles enable coordinated mucosal-systemic immunity for durable pan-β-coronavirus protection

待确认 10 由 Jehiah 发布于 2026/9/8 15:07:00

DOI:10.1038/s41565-026-02188-z
作者：Zezhong Liu, Jie Zhou, Ruiyu Gao, Yanqun Wang, Meiqin Liu, Weijie Wang, Yuanzhou Wang, Peilan Wei, Kaicheng Zhou, Muzhuo Wang, Shaokun Pan, Lixia
文献类型：期刊论文
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Nature

Abstract：A major barrier in mucosal vaccine development is achieving localized immunity without systemic toxicity. Here we engineered NanoCF501, a nanoparticulate STING agonist formulated with a 2-et

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