A rapid imaging-based screen for induced-proximity degraders identifies a potent degrader of oncoprotein SKP2

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DOI:10.1038/s41587-025-02793-8
作者：Yankai Chu, Shishuang Chen, Mingyang Yang, Yin Chen, Huiling Fang, Pinyu Huang, Yueru Xie, Chi Sun, Yun Chen, Baoding Zhang, Li Li, Hongchen Mu,&
文献类型：期刊论文
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Nature

Abstract：Targeted protein degraders hold potential as therapeutic agents to target conventionally ‘undruggable’ proteins. Here, we develop a high-throughput screen, DEath FUSion Escaper (DEFUSE), to

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