Pseudokinase STK40 limits T cell exhaustion through COP1-dependent degradation of AP1-family transcription factors

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DOI:10.1038/s41590-025-02333-1
作者：Svetlana Altshuler-Keylin,?Nicole Caduff,?Isabel E. Ishizuka,?Rohit Reja,?Katherine Nutsch,?Chan Gao,?Joy Wang,?Ulrike Kaufmann,?Mayra Cruz Tleugabulova,?Elizabeth Dixon,?Hannah Little-Hooy,?Rachana P
文献类型：期刊论文
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Nature

Abstract：Serine/threonine kinase 40 (STK40) belongs to the Tribbles family of pseudokinases, which serve as substrate adaptors for the CRL4COP1/DET1 E3 ubiquitin ligase complex. Tribbles-1 and Tribbl

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