Contradictory Effects of Different Freezing Rates on Visible Bubbles and Reconstitution Time during the Reconstitution of Freeze-Dried High-Concentration Monoclonal Antibody Formulations

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DOI:10.1021/acs.molpharmaceut.5c01347
作者：Han Gao,?, ,?Yi-Mei Sun,?, ,?Jun Ouyang,?, ,?Zhao-Lin Ding,?, ,?Chang-Yun Xiong,?, ,?You-Ru Wang,?, ,?Rui Xing,?, and ,?Wei-Jie Fang*,?
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：The freezing rate is a critical factor governing ice nucleation and growth during freeze-drying, which directly determines the microvoid architecture of the freeze-dried cake and its reconst

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