Thrombospondin-1–CD47 signaling contributes to the development of T cell exhaustion in cancer

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DOI:10.1038/s41590-025-02321-5
作者：Chien-Huan Weng,?Anais Assouvie,?Lauren Dong,?Jean-Christophe Beltra,?Sadna Budhu,?Levi Mangarin,?Yacine Marouf,?Lucia Morgado-Palacin,?Cailian Liu,?Sébastien Monette,?Jonathan F. Khan,?Isabell Schul
文献类型：期刊论文
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Nature

Abstract：T cell exhaustion is a major barrier to effective cancer immunotherapy. Although immune checkpoint blockade can reinvigorate exhausted T cells, not all patients achieve long-term responses,

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