Design and Synthesis of Novel Cereblon Binders for Use in Targeted Protein Degradation

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DOI:10.1021/acs.jmedchem.3c01848
作者：Stephen Norris*,?Xiaochu Ba,?Jayce Rhodes,?Dehua Huang,?Gody Khambatta,?Jennifer Buenviaje,?Surendra Nayak,?Joseph Meiring,?Samantha Reiss,?Shuichan Xu,?Lihong Shi,?Brandon Whitefield,?Matt Alexander,
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Abstract：Modulating the chemical composition of cereblon (CRBN) binders is a critical step in the optimization process of protein degraders that seek to hijack the function of this E3 ligase. Small s

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