Retargeted oncolytic viruses engineered to remodel the tumor microenvironment for glioblastoma immunotherapy

已完结 20 由 hikking 发布于 2026/6/22 16:40:29

DOI:10.1038/s43018-025-01070-6
文献类型：期刊论文
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文献链接：https://doi.org/10.1038/s43018-025-01070-6

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Abstract：Glioblastoma (GBM) is an aggressive, immunotherapy-resistant brain tumor. Here, we engineered an oncolytic virus platform based on herpes simplex virus 1 for GBM viroimmunotherapy. We mutate

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