A convergent uPAR-positive tumor ecosystem creates broad vulnerability to CAR T cell therapy.

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DOI:10.1016/j.cell.2026.03.002
作者：Zeda Zhang,?Yu-Jui Ho,?Xin Fang,?Minseo Kim,?Marguerite Li,?Wei Luan,?Clemens Hinterleitner,?Sascha Haubner,?Friederike Kogel,?Edwin C Pratt,?Elif Ozcelik,?José Reyes,?Qingwen Jiang,?Vincent W Yang,?
文献类型：期刊论文
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Elsevier

Abstract：Chimeric antigen receptor (CAR) T cells have transformed hematologic cancer therapy but remain limited in solid tumors by antigen heterogeneity and a suppressive, pro-fibrotic microenvironme

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