Iron-mediated ferroptosis impairs CAR-T cell function and antitumor efficacy.

已完结 10 由 Penny Ding 发布于 2026/6/23 14:46:09

DOI:10.1038/s43018-026-01187-2
作者：Delin Kong, Tingting Yang, Mengyu Zhao, Lin Yang, Ruirui Jing, Youqin Feng, Shaohui Shi, Zhouning Lin, Shi Han, Cong Wei, Rongrong Chen, Qiqi Zha
文献类型：期刊论文
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Nature

Abstract：Long-term persistence of chimeric antigen receptor (CAR)-T cells is essential for durable therapeutic efficacy but the mechanisms underlying CAR-T cell dysfunction remain unclear. On the bas

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