SMARCA4 loss increases RNA Polymerase II pausing and elevates R-loops to inhibit BRCA1-mediated repair in ovarian cancer.

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DOI:10.1158/0008-5472.can-24-3990
作者：Xianbing Zhu,Zheng Fu,Giulio Aceto,Jonathan St-Germain,Kexin Liu,Azadeh Arabzadeh,Yuxuan Qi,Yibo Xue,Leora Witkowski,Elise Graulich,Jutta Steinberger,Selim Misirlioglu,Nicklas Bassani,Racim Sansal,Amb
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American Association for Cancer Research (AACR)

Abstract：Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare, aggressive cancer affecting young women, driven by inactivating mutations in SMARCA4, a key SWI/SNF chromatin remode

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