Structure-based design of a novel third-generation antipsychotic drug lead with potential antidepressant properties

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DOI:10.1038/s41593-021-00971-w
作者：Zhangcheng Chen,?Luyu Fan,?Huan Wang,?Jing Yu,?Dengyu Lu,?Jianzhong Qi,?Fen Nie,?Zhipu Luo,?Zhen Liu,?Jianjun Cheng,?Sheng Wang
文献类型：期刊论文
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Nature

Abstract：Partial agonist activity at the dopamine D2 receptor (DRD2) is a key feature of third-generation antipsychotics (TGAs). However, TGAs also act as antagonists or weak partial agonists to the

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