Transferrin receptor targeting chimeras for membrane protein degradation

待确认 10 由 margauxx 发布于 2026/6/29 17:11:52

DOI:10.1038/s41586-024-07947-3
作者：Dingpeng Zhang,?Jhoely Duque-Jimenez,?Francesco Facchinetti,?Garyk Brixi,?Kaitlin Rhee,?William W. Feng,?Pasi A. J?nne,?Xin Zhou
文献类型：期刊论文
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Nature

Abstract：Cancer cells require high levels of iron for rapid proliferation, leading to significant upregulation of cell-surface transferrin receptor 1 (TfR1), which mediates iron uptake by binding to

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