Integrative Chemical Proteomics and Metabolomics Identify AHCY as the Direct Target of Triptolide-induced Liver Injury

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DOI:10.1016/j.phymed.2025.157683
作者：Qiao-Lei Wang ,?Fang-Ning Qiu ,?Er-Chong Li ,?Xin-Mei Wu ,?Ping Li ,?Yan Jiang ,?Hui-Jun Li
文献类型：期刊论文
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Elsevier

Abstract：BackgroundTriptolide (TP), a bioactive compound derived from Tripterygium wilfordii, exhibits potent immunosuppressive activity but is limited in clinical application due to hepatotoxicity e

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