Design of Potent and Selective BCL6 Transcriptional Chemical Inducers of Proximity through Linker Optimization.

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DOI:10.1021/acs.jmedchem.6c00756
作者：Fang-Chi Chang,Veronika M Shoba,Oleh Shyshlyk,Andrii Frolov,Daniil Skrypnik,Halyna Bubela,Yuliia Holota,Corentine M C Laurin,Rodrigo A Rodriguez,C Avery Sader,Timur Savchenko,Petro Borysko,Armand B Co
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：B-cell lymphoma 6 (BCL6) is a transcriptional repressor implicated in diffuse large B-cell lymphoma and other malignancies. Conventional BCL6 inhibitors and degraders rely on loss-of-functio

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