SIRT3 regulates PFKFB3-mediated glycolysis to attenuate cisplatin-induced ototoxicity both in vivo and in vitro

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DOI:10.1007/s00204-025-03975-8
作者：Wei Tang,?Shimin Zong,?Peiyu Du,?Xuan Yu,?Ting Li,?Bo Liu,?Yu Zhong,?Wenyang Lei,?Wenting Yu,?Hongjun Xiao
文献类型：期刊论文
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Springer

Abstract：Cochlear hair cell death is the primary cause of cisplatin-induced ototoxicity, currently lacking widely applicable clinical methods for effective prevention and treatment. In this study, an

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