Lysosome-targeted degradation of leucine-rich alpha-2 glycoprotein 1 enables chemosensitization to 5-fluorouracil in colorectal cancer

已完结 10 由哒哒哒我发布于 2026/6/5 19:28:07

DOI:10.1016/j.jconrel.2026.114962
作者：Gang Wu , Kejuan Zhang , Huan Min , Lin Du , Junyao Li , Wenzheng Li , Yinlong Zhang , Shengnan Du , Yingqiu Qi , Wei Zhang
文献类型：期刊论文
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Elsevier

Abstract：Leucine-rich α-2-glycoprotein 1 (LRG1) is markedly upregulated in colorectal cancer (CRC) and correlates with a poor prognosis, yet its role in drug response remains unclear. Here, we identi

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