Breaking the immunosuppressive barrier: an armored CAR-M biotechnology with the original M1 phenotype dominance rescues antitumor immunity.

已完结 10 由 Faye 发布于 2026/6/6 14:24:56

DOI:10.1016/j.tibtech.2026.02.011
作者：Fuyu Du, Yuanhui Xu, Wenhui Chu, Jingjing Qiu, Meixi Jiang, Xinruo Wang, Dashan Guan, Maozhi Su, Anna He, Zixuan Ye, Yuqiong Xia, Xianghan Zhang,
文献类型：期刊论文
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Elsevier

Abstract：Chimeric antigen receptor macrophages (CAR-Ms) hold promise for solid tumor immunotherapy, but their efficacy is limited by tumor microenvironment (TME)-driven M2 polarization. Current strat

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