Rapid Multikilogram Scale-Up of Di- and Trifluoromethoxy Proline Derivatives

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DOI:10.1021/acs.oprd.3c00493
文献类型：期刊论文
补充材料：只需要正文
文献链接：https://doi.org/10.1021/acs.oprd.3c00493

American Chemical Society (ACS)

Abstract：This report describes the synthesis, development, and scale-up (up to 10 kg) of di- and trifluoromethoxy prolines, key fragments evaluated in the development of potential antiviral SARS-CoV2

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