Nitrate-responsive genetically engineered probiotics locally release TNF-α nanobodies against inflammatory bowel disease

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DOI:10.1016/j.jconrel.2026.114666
作者：Bochuan Yuan ,?Zhangyu Li ,?Yuanyuan Song ,?Yaqian Zhang ,?Feng Zhang ,?Ke Wang ,?Lina Du ,?Yiguang Jin
文献类型：期刊论文
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Elsevier

Abstract：The clinical potential of oral genetically engineered probiotics is widely recognized, which is usually distinguished by the release of expressed active molecules. However, the impact of the

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