Discovery of 4-((3′R,4′S,5′R)-6″-Chloro-4′-(3-chloro-2-fluorophenyl)-1′-ethyl-2″-oxodispiro[cyclohexane-1,2′-pyrrolidine-3′,3″-indoline]-5′-carboxamido)bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine Double Minute 2 (MDM2) Inhibitor in Clinical Development

已完结 10 由 123 发布于 2026/3/3 17:43:24

DOI:10.1021/acs.jmedchem.6b01665
文献类型：期刊论文
补充材料：只需要正文
文献链接：https://doi.org/10.1021/acs.jmedchem.6b01665

American Chemical Society (ACS)

Abstract：We previously reported the design of spirooxindoles with two identical substituents at the carbon-2 of the pyrrolidine core as potent MDM2 inhibitors. In this paper we describe an extensive

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