VDAC1-mediated cytosolic leakage of mtDNA triggers pyroptosis of nucleus pulposus cells by activating the TLR9 signaling pathway

待确认 10 由 benpaoxiaoxiong 发布于 2026/6/14 11:18:23

DOI:10.1016/j.cellsig.2026.112387
作者：Tonglong Hu ,?Miaoheng Yan ,?Yangyang Chen ,?Songfeng Chen ,?Zongmian Song ,?Xiaobo Jing ,?Binwu Hu ,?Hongjian Liu
文献类型：期刊论文
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Elsevier

Abstract：Programmed cell death, particularly pyroptosis mediated by inflammatory signaling pathways, plays a critical role in the pathogenesis of intervertebral disc degeneration (IVDD). However, the

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