Hiding Payload Inside the IgG Fc Cavity Significantly Enhances the Therapeutic Index of Antibody–Drug Conjugates

已完结 10 由少年发布于 2026/3/10 10:59:58

DOI:10.1021/acs.jmedchem.2c01812
作者：Wei Shi, Jianxin Zhang, Liya Liu, Wanzhen Li, Zhi Liu, Anni Ren, Jie Wang, Caihong Tang, Yang Yang, Dandan Xu, Qianqian Huang, Yongqin Wang,&nbsp
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：The inadequate understanding of the structure–activity relationship (SAR) of glycosite-specific antibody–drug conjugates (ADCs) hinders its design and development. Herein, we revealed the sy

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