Targeting the ER stress sensor IRE1 protects the liver from fibrosis through the downregulation of the proteostasis factor P4HB/PDIA1.

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DOI:10.1097/HEP.0000000000001335
作者：Younis Hazari,?Lama Habbouche,?Valeria A Garcia Lopez,?Hery Urra,?Javier Diaz,?Giovanni Tamburini,?Mateus Milani,?Sylvere Durand,?Fanny Aprahamian,?Reese Baxter,?Menghao Huang,?X Charlie Dong,?Luis Go
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Wolters Kluwer Ovid

Abstract：Background aims: Collagen is the main cargo of the secretory pathway, contributing to hepatic fibrogenesis due to extensive accumulation of extracellular matrix. An excess of collagen deposi

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