Amino acid supplementation enhances in vivo efficacy of lipid nanoparticle-mediated mRNA delivery in preclinical models.

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DOI:10.1126/scitranslmed.adx4097
作者：Kangfu Chen,Wenhan Wang,Amber Lennon,Ryan A McClure,Aleksandra Vuchkovska,Shana O Kelley,Zongjie Wang
文献类型：期刊论文
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Abstract：Lipid nanoparticles (LNPs) play a critical role in the delivery of therapeutic messenger RNA (mRNA). Despite extensive efforts to optimize lipid formulations for in vivo delivery, efficacy o

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