A Two-Tiered In Vitro Approach to De-Risk Drug Candidates for Potential Bile Salt Export Pump Inhibition Liabilities in Drug Discovery.

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DOI:10.1124/dmd.120.000086
作者：Michael J Hafey,?Robert Houle,?Keith Q Tanis,?Ian Knemeyer,?Jackie Shang,?Qing Chen,?Andreas Baudy,?James Monroe,?Frank D Sistare,?Raymond Evers
文献类型：期刊论文
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Elsevier

Abstract：Hepatocellular accumulation of bile salts by inhibition of bile salt export pump (BSEP/ABCB11) may result in cholestasis and is one proposed mechanism of drug-induced liver injury (DILI). To

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