Intratumoral radiation dose heterogeneity augments antitumor immunity in mice and primes responses to checkpoint blockade

已完结 10 由 Susan Buttlar 发布于 2026/2/9 10:09:52

DOI:10.1126/scitranslmed.adk0642
作者：Justin C. Jagodinsky,?Jessica M. Vera,?Won Jong Jin,?Amanda G. Shea,?Paul A. Clark,?Raghava N. Sriramaneni,?Thomas C. Havighurst,?Ishan Chakravarthy,?Raad H. Allawi,?KyungMann Kim,?Paul M. Harari,?Pau
文献类型：期刊论文
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American Association for the Advancement of Science (AAAS)

Abstract：Radiation therapy (RT) activates multiple immunologic effects in the tumor microenvironment (TME), with diverse dose-response relationships observed. We hypothesized that, in contrast with h

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