Universal Base-Edited CAR7 T Cells for T-Cell Acute Lymphoblastic Leukemia.

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DOI:10.1056/NEJMoa2505478
作者：Robert Chiesa, Christos Georgiadis, Hebatalla Rashed, Roland Preece, Prudence Hardefeldt, Jan Chu, Jemma Selvage, Avijeet Mishra, Batoul Ahmed, Stuart Adam
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New England Journal of Medicine (NEJM)

Abstract：Background: CD7 is an attractive target for chimeric antigen receptor (CAR) T-cell therapy in relapsed or refractory T-cell acute lymphoblastic leukemia (ALL). Supportive results of first-in

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