Discovery of Ervogastat (PF-06865571): A Potent and Selective Inhibitor of Diacylglycerol Acyltransferase 2 for the Treatment of Non-alcoholic Steatohepatitis

求助中 10 由 brooky 发布于 2026/2/23 8:59:19

DOI:10.1021/acs.jmedchem.2c01200
作者：Kentaro Futatsugi*, Shawn Cabral, Daniel W. Kung*, Kim Huard, Esther Lee, Markus Boehm, Jonathan Bauman, Ronald W. Clark, Steven B. Coffey, Collin Crowley,
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American Chemical Society (ACS)

Abstract：Discovery efforts leading to the identification of ervogastat (PF-06865571), a systemically acting diacylglycerol acyltransferase (DGAT2) inhibitor that has advanced into clinical trials for

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