Rapid directed evolution guided by protein language models and epistatic interactions

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DOI:10.1126/science.aea1820
作者：Vincent Q. Tran, Matthew Nemeth, Liam J. Bartie, Sita S. Chandrasekaran, Alison Fanton, Hyungseok C. Moon, Brian L. Hie, Silvana Konermann, Patrick D. Hsu
文献类型：期刊论文
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American Association for the Advancement of Science (AAAS)

Abstract：Protein engineering is limited by the inefficient search through a high-dimensional sequence space to find combinations of synergistic mutations. Traditional approaches use stepwise mutation

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