Optimization of Pharmacokinetic and In Vitro Safety Profile of a Series of Pyridine Diamide Indirect AMPK Activators

已完结 10 由龙行天下发布于 2026/2/27 13:27:57

DOI:10.1021/acs.jmedchem.3c01983
作者：Simon J. Shaw, Dane A. Goff, Luke A. Boralsky, Rajinder Singh, David J. Sweeny, Gary Park, Tian-Qiang Sun, Yonchu Jenkins, Vadim Markovtsov, Sarkiz D. Issakani, Donald G. Payan, Yasumichi Hitoshi
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：A set of focused analogues have been generated around a lead indirect adenosine monophosphate-activated kinase (AMPK) activator to improve the rat clearance of the molecule. Analogues were f

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