Identification and Characterization of Highly Potent and Isoenzyme-Selective Inhibitors of Deiodinase Type I via a Nonradioactive High-Throughput Screening Method.

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DOI:10.1089/thy.2025.0036
作者：Rajas Sane, Carola Seyffarth, Sabrina Kleissle, Martin Neuenschwander, Jens Peter von Kries, Caroline Fr?drich, Kostja Renko, Eva K Wirth, Josef K?hrle
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Abstract：Objective: Deiodinase type I (DIO1) is crucial in maintaining thyroid hormone (TH) balance. It converts the prohormone thyroxine (T4) to the active triiodothyronine (T3) and degrades T3 to i

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