Discovery and Optimization of Selective Inhibitors of Large Tumor Suppressor Kinases LATS1 and 2 for In Vivo Investigation of the Hippo-YAP Pathway in Tissue Regeneration

已完结 10 由饼干发布于 2026/4/1 13:45:42

DOI:10.1021/acs.jmedchem.5c00350
作者：Kenji Namoto*, Eric Vangrevelinghe, Rainer Machauer, Dirk Behnke, Nicole Buschmann, Julie Lachal, Kathrin Schipp, Mickael Sorge, Kerstin Barker, Francesca
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：Large Tumor Suppressor kinases LATS1 and 2 (LATS1/2) are serine/threonine kinases and core regulators of the Hippo-YAP pathway. Inhibition of LATS1/2 promotes nuclear translocation of nonpho

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