Enzyme-Catalyzed Intramolecular C–C Coupling Transformation of Nitriles

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DOI:10.1021/jacs.6c02210
作者：Chaonan Zhu, , , Dongqi Wu, , , Yinhong Lai, , , Huangong Li, , , Rui Pan, , , Keke Zou, , , Qi Chen, , , Guoliang Zhu, , ,&n
文献类型：期刊论文
补充材料：只需要正文

American Chemical Society (ACS)

Abstract：Nitrile C–C coupling transformation, currently absent from existing biocatalytic toolbox, is a pivotal objective in enzyme catalysis. Herein, we engineered a ThDP-dependent enzyme to achieve

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