Targeting PTPN2 enhances human CAR T cell efficacy and the development of long-term memory in mouse xenograft models

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DOI:10.1126/scitranslmed.adk0627
作者：Xin Du,&nbsp;Pei K. Goh,&nbsp;Chenkai Ma,&nbsp;Eamon Coughlan,&nbsp;Spencer Greatorex,&nbsp;Laura H. Porter,&nbsp;Brendan Russ,&nbsp;Katherine D. Cummins,&nbsp;Kevin Se
文献类型：期刊论文
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American Association for the Advancement of Science (AAAS)

Abstract：Chimeric antigen receptor (CAR) T cells have been ineffective against solid tumors, where the hostile tumor microenvironment limits CAR T cell function and persistence. Protein tyrosine phos

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