Targeted Lipid Nanoparticle Delivery of FAP-CAR mRNA Enables Potent In Vivo T-cell Engineering against Pancreatic Tumors.

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DOI:10.1158/2326-6066.CIR-25-0663
作者：Khuloud Bajbouj, Zebin Xiao, Leslie Todd, Li Huang, Tyler E Papp, Faris Halilovic, Jayalakshmi Ramani, Yanjie Bao, Matthew Butcher, Adrian Bot, Haig A
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American Association for Cancer Research (AACR)

Abstract：Fibroblast activation protein (FAP), which is highly expressed on cancer-associated fibroblasts (CAF), is a promising therapeutic target to achieve normalization of the tumor microenvironmen

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