Platelet-derived integrin- and tetraspanin-enriched tethers exacerbate severe inflammation

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DOI:10.1126/science.adu2825
作者：Charly Kusch, David Stegner, Lukas J. Weiss, Paquita Nurden, Philipp Burkard, Denise Johnson, Wolfgang Bergmeier, Ceylan Onursal, Stefano Navarro, Christia
文献类型：期刊论文
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American Association for the Advancement of Science (AAAS)

Abstract：Platelet integrin αIIbβ3 is essential for hemostasis, thrombosis, and inflammation. We found that ligation of αIIbβ3 by von Willebrand factor or fibrin under flow triggered its accumulation

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