The gut microbiota alleviates depression by remodeling gut-brain energy metabolism

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DOI:10.1016/j.cmet.2026.03.002
作者：Cheng-Lin Lu, Jing Ren, Yueshiyuan Lei, Xiao-Ying Lian, Hao-Tian Jiang, Fang Guo, Liang-Yu Chen, Jia-Wen Mo, Hongyun Mao, Jun Fan, Guangyan Wu, Wan-Qian Ye, You-Lu Wen, Haitao Sun, Yan He, Jiubo Zhao,
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Elsevier

Abstract：Although peripheral-brain crosstalk regulates energy metabolism, its role in depression remains unclear. Here, we used metabolic profiling to reveal elevated fecal creatine alongside reduced

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