Mining the CRBN target space redefines rules for molecular glue–induced neosubstrate recognition

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DOI:10.1126/science.adt6736
作者：Georg Petzold,?Pablo Gainza,?Stefano Annunziato,?Ilaria Lamberto,?Peter Trenh,?Laura A. McAllister,?Bradley DeMarco,?Laura Schwander,?Richard D. Bunker,?Mary Zlotosch,?Rohitha SriRamaratnam,?Samuel Gi
文献类型：期刊论文
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American Association for the Advancement of Science (AAAS)

Abstract：The CRL4CRBN E3 ubiquitin ligase is the target of molecular glue degrader compounds that reprogram ligase specificity to induce the degradation of clinically relevant neosubstrate proteins.

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