LC-MS/MS combined with blood-brain dual channel microdialysis for simultaneous determination of active components of astragali radix-safflower combination and neurotransmitters in rats with cerebral ischemia reperfusion injury: Application in pharmacokinetic and pharmacodynamic study

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DOI:10.1016/j.phymed.2022.154432
作者：Yu Du ,?Chang Li ,?Shouchao Xu ,?Jiehong Yang ,?Haitong Wan ,?Yu He
文献类型：期刊论文
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Elsevier

Abstract：BackgroundAstragali Radix-Safflower combination (ARSC) is widely utilized in clinic to treat cerebral ischemia/reperfusion injury (CI/RI). Whereas, there is no in-depth research of the pharm

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